MESSAGE
| DATE | 2020-09-25 |
| FROM | Ruben Safir
|
| SUBJECT | Subject: [Hangout - NYLXS] mutation into a superbug and Faucci
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FWIW - I have repeatedly said that if we continue to use masks and
sanitizers as the front line method of combating viral spread, which is
a technique that is used in hospitals to protect from infectious
disease, that two things will almost certainly be a result:
A) The strategy will largely fail, and no study has proven otherwise --
NONE. The reason or this is plain and any objective individual can
understand this. Hospitals that carry this technique have trained
professional personnel that maintain infection control within their
institutions. This is not dissimilar to combat soldiers in the field,
who are on a heighten level of awareness, and stress in order to survive
and fight to win. But these trained professionals continually FAIL to
do this adequately, and noscromal infections continue to rage, without
exception, in every institution in the world. The task, while
admirable, and needed inside institutions, and while it is a linchpin to
modern healthcare, is impossible to do by human beings over long periods
of time, and professionals fail at it all the time. The benefits of
doing this, never the less, in the hospital means that we need to
continually to work on this standard every day because every failure,
and they happen all the time, costs lives and harms patients. But
OUTSIDE the hospital and in the general public, not only will this
continued failure rate carry over, but it will be far worst. Your
asking non-trained people in the general public to behave in a
heightened modality that will not only fail, but it is a major stressors
on the individual personalities of everyone involved, fueling further
personality disorders, depression, suicides, societal breakdowns, and
acts of violence, all of which is today proving to be more deadly and
dangerous than the virus.
B) The result of extended use of these institutional protocols is
Super-Bugs. These are mutated organisms that evolve to survive under
environmental strains, and become, often, highly contagious and deadly
organism that further resist treatment.
I am tired of being mocked about these to rational, central,
historically based and scientifically sustained points, especially but
supposed educated lay people living in a state of paranoid delusion.
Mostly, I hate the Loshen Harah, and attack on my reputation, as if I
live in my own delusional bubble, and these so called lay experts with
access to medical papers are somehow expert, not to mention the attacks
on my 30+ years in the healthcare field taking care of patients.
Now - just to add something slightly off topic on this message, I really
hate Faucci. He is dishonest, arrogant and prick. In his testimony
this week with Rand Paul that we can see here
https://www.realclearpolitics.com/video/2020/09/23/fauci_to_sen_rand_paul_if_you_think_22_is_herd_immunity_i_believe_youre_alone_in_that.html
Faucci is KNOWINGLY lying here on two fronts, and Andrew Cuomo did the
same thing. The 22% Faucci is bragging about here is actually quite
substantial and it is possibility a major factor slowing the veracity
and contagiousness of a second wave in New York. As a fact, we just
don't know and there are several new articles and studies trying to
understand why epidemiological models aren't coinciding with the
resistance that NY is actually offering to a second wave. It has to
come. It is not rational to think we can avoid a second wave,
especially when the governments response is to lock everyone in a room
and isolate everyone.
But the real lie for Faucci is his using the statistics for the WHOLE of
New York State when the virus hot zones during the height of the
contagion in New York we have nearly 70% positives coming through the
door at hospitals and ERS in the central Bronx, Brooklyn and Queens. We
also have evidence that IGG and IGM only show for a short period of time
in patients that still have immunity through memory B-Cells, and those
don't even read as positive. And we still, as clinicians in the public,
have thousands of cases when people who would seemingly have to have
gotten infected because of close contact and living with family members
and workers, seemingly show up as COVID-19 negative? And that is also
not explained, unless these people are genetically resistant by an
unknown mechanism, greatly reducing the number we needed for herd
immunity, or that they had the virus so long ago that they never show up
as positive for either RNA strands or anti-bodies. Either way, Faucci
knows this, and he is a big fat liar and a dangerous man to be holding
any power over the public.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
medrxiv.org
Molecular Architecture of Early Dissemination and Massive Second Wave of
the SARS-CoV-2 Virus in a Major Metropolitan Area
Scott Wesley Long
5-6 minutes
, Randall J Olsen, Paul A. Christensen, David W Bernard, James J. Davis,
Maulik Shukla, Marcus Nguyen, Matthew Ojeda Saavedra, Prasanti
Yerramilli, Layne Pruitt, Sishir Subedi, Hung-Che Kuo, Heather
Hendrickson, Ghazaleh Eskandari, Hoang A.T. Nguyen, James Hunter Long,
Muthiah Kumaraswami, Jule Goike, Daniel Boutz, Jimmy Gollihar, Jason S.
McLellan, Chia-Wei Chou, Kamyab Javanmardi, Ilya J. Finkelstein, James
Musser
doi: https://doi.org/10.1101/2020.09.22.20199125
Abstract
We sequenced the genomes of 5,085 SARS-CoV-2 strains causing two
COVID-19 disease waves in metropolitan Houston, Texas, an ethnically
diverse region with seven million residents. The genomes were from
viruses recovered in the earliest recognized phase of the pandemic in
Houston, and an ongoing massive second wave of infections. The virus was
originally introduced into Houston many times independently. Virtually
all strains in the second wave have a Gly614 amino acid replacement in
the spike protein, a polymorphism that has been linked to increased
transmission and infectivity. Patients infected with the Gly614 variant
strains had significantly higher virus loads in the nasopharynx on
initial diagnosis. We found little evidence of a significant
relationship between virus genotypes and altered virulence, stressing
the linkage between disease severity, underlying medical conditions, and
host genetics. Some regions of the spike protein - the primary target of
global vaccine efforts - are replete with amino acid replacements,
perhaps indicating the action of selection. We exploited the genomic
data to generate defined single amino acid replacements in the receptor
binding domain of spike protein that, importantly, produced decreased
recognition by the neutralizing monoclonal antibody CR30022. Our study
is the first analysis of the molecular architecture of SARS-CoV-2 in two
infection waves in a major metropolitan region. The findings will help
us to understand the origin, composition, and trajectory of future
infection waves, and the potential effect of the host immune response
and therapeutic maneuvers on SARS-CoV-2 evolution.
Competing Interest Statement
The authors have declared no competing interest.
Funding Statement
We are indebted to Drs. Marc Boom and Dirk Sostman for their support,
and to many very generous Houston philanthropists for their tremendous
support of this ongoing project, including but not limited to anonymous,
Ann and John Bookout III, Carolyn and John Bookout, Ting Tsung and Wei
Fong Chao Foundation, Ann and Leslie Doggett, Freeport LNG, the Hearst
Foundations, Jerold B. Katz Foundation, C. James and Carole Walter
Looke, Diane and David Modesett, the Sherman Foundation, and Paula and
Joseph C. (Rusty) Walter III.
Author Declarations
I confirm all relevant ethical guidelines have been followed, and any
necessary IRB and/or ethics committee approvals have been obtained.
Yes
The details of the IRB/oversight body that provided approval or
exemption for the research described are given below:
Houston Methodist IRB Approved Protocol IRB1010-0199
All necessary patient/participant consent has been obtained and the
appropriate institutional forms have been archived.
Yes
I understand that all clinical trials and any other prospective
interventional studies must be registered with an ICMJE-approved
registry, such as ClinicalTrials.gov. I confirm that any such study
reported in the manuscript has been registered and the trial
registration ID is provided (note: if posting a prospective study
registered retrospectively, please provide a statement in the trial ID
field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines and
uploaded the relevant EQUATOR Network research reporting checklist(s)
and other pertinent material as supplementary files, if applicable.
Yes
Data Availability
The SARS-CoV-2 genomes described herein have all been deposited in
GISAID and are publically available.
--
So many immigrant groups have swept through our town
that Brooklyn, like Atlantis, reaches mythological
proportions in the mind of the world - RI Safir 1998
http://www.mrbrklyn.com
DRM is THEFT - We are the STAKEHOLDERS - RI Safir 2002
http://www.nylxs.com - Leadership Development in Free Software
http://www.brooklyn-living.com
Being so tracked is for FARM ANIMALS and extermination camps,
but incompatible with living as a free human being. -RI Safir 2013
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