MESSAGE
| DATE | 2020-03-17 |
| FROM | Ruben Safir
|
| SUBJECT | Subject: [Hangout - NYLXS] COVID-19 and ME!
|
https://link.springer.com/article/10.1007/s00134-020-05991-x
Letter
Published: 03 March 2020
Clinical predictors of mortality due to COVID-19 based on an analysis of
data of 150 patients from Wuhan, China
Qiurong Ruan, Kun Yang, Wenxia Wang, Lingyu Jiang & Jianxin Song
Intensive Care Medicine (2020)Cite this article
51k Accesses
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Dear Editor,
The rapid emergence of COVID-19 in Wuhan city, Hubei Province, China,
has resulted in thousands of deaths [1]. Many infected patients,
however, presented mild flu-like symptoms and quickly recover [2]. To
effectively prioritize resources for patients with the highest risk, we
identified clinical predictors of mild and severe patient outcomes.
Using the database of Jin Yin-tan Hospital and Tongji Hospital, we
conducted a retrospective multicenter study of 68 death cases (68/150,
45%) and 82 discharged cases (82/150, 55%) with laboratory-confirmed
infection of SARS-CoV-2. Patients met the discharge criteria if they had
no fever for at least 3 days, significantly improved respiratory
function, and had negative SARS-CoV-2 laboratory test results twice in
succession. Case data included demographics, clinical characteristics,
laboratory results, treatment options and outcomes. For statistical
analysis, we represented continuous measurements as means (SDs) or as
medians (IQRs) which compared with Student’s t test or the
Mann–Whitney–Wilcoxon test. Categorical variables were expressed as
numbers (%) and compared by the χ2 test or Fisher’s exact test.
The distribution of the enrolled patients’ age is shown in Fig. 1a.
There was a significant difference in age between the death group and
the discharge group (p < 0.001) but no difference in the sex ratio
(p = 0.43). A total of 63% (43/68) of patients in the death group and
41% (34/82) in the discharge group had underlying diseases (p = 0.0069).
It should be noted that patients with cardiovascular diseases have a
significantly increased risk of death when they are infected with
SARS-CoV-2 (p < 0.001). A total of 16% (11/68) of the patients in the
death group had secondary infections, and 1% (1/82) of the patients in
the discharge group had secondary infections (p = 0.0018). Laboratory
results showed that there were significant differences in white blood
cell counts, absolute values of lymphocytes, platelets, albumin, total
bilirubin, blood urea nitrogen, blood creatinine, myoglobin, cardiac
troponin, C-reactive protein (CRP) and interleukin-6 (IL-6) between the
two groups (Fig. 1b and Supplementary Table 1).
--
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